Association of poly-purine/poly-pyrimidine sequences with meiotic recombination hot spots.

ABSTRACT:

Background

Meiotic recombination events have been found to concentrate in 1-2.5 kilo base regions, but these recombination hot spots do not share a consensus sequence and why they occur at specific sites is not fully understood. Some previous evidence suggests that poly-purine/poly-pyrimidine (poly-pu/py) tracts (PPTs), a class of sequence with distinctive biochemical properties, could be involved in recombination, but no general association of PPTs with meiotic recombination hot spots has previously been reported.

Results

We used computational methods to investigate in detail the relationship between PPTs and hot spots. We show statistical associations of PPT frequency with hot spots of meiotic recombination initiating lesions, double-strand breaks, in the genome of the yea

SUBMITTER: Bagshaw AT 

PROVIDER: S-EPMC1543642 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature