Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision.
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ABSTRACT:
SUBMITTER: Cursiefen C
PROVIDER: S-EPMC1544098 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
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Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision.
Cursiefen Claus C Chen Lu L Saint-Geniez Magali M Hamrah Pedram P Jin Yiping Y Rashid Saadia S Pytowski Bronislaw B Persaud Kris K Wu Yan Y Streilein J Wayne JW Dana Reza R
Proceedings of the National Academy of Sciences of the United States of America 20060718 30
Transparency of the cornea, the window of the eye, is a prerequisite for vision. Angiogenesis into the normally avascular cornea is incompatible with good vision and, therefore, the cornea is one of the few tissues in the human body where avascularity is actively maintained. Here, we provide evidence for a critical mechanism contributing to corneal avascularity. VEGF receptor 3, normally present on lymphatic and proliferating blood vascular endothelium, is strongly constitutively expressed by co ...[more]
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