Robust, bistable patterning of the dorsal surface of the Drosophila embryo.

ABSTRACT: In many developing systems, the fate of a cell is determined by its position in a time-independent spatial distribution of a morphogen. However, during dorsal-ventral patterning in the Drosophila embryo, an initial low-level signal refines to a narrow, high-intensity band. This refinement suggests that cells respond to the local transient morphogen distribution that results from interactions between bone morphogenetic proteins (BMPs), their receptors, the BMP-binding proteins Sog and Tsg, the metalloprotease Tld, and a putative, positively regulated component that locally enhances surface binding of BMPs within the region of high signaling. We develop a computational model for dorsal surface patterning and show that, when positive feedback of a cell surface BMP-binding protein is incorpora

SUBMITTER: Umulis DM 

PROVIDER: S-EPMC1544218 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature