Non-random clustering of stress-related genes during evolution of the S. cerevisiae genome.

ABSTRACT:

Background

Coordinately regulated genes often physically cluster in eukaryotic genomes, for reasons that remain unclear.

Results

Here we provide evidence that many S. cerevisiae genes induced by starvation and other stresses reside in non-random clusters, where transcription of these genes is repressed in the absence of stress. Most genes essential for growth or for rapid, post-transcriptional responses to stress in cycling cells map between these gene clusters. Genes that are transcriptionally induced by stresses include a large fraction of rapidly evolving paralogues of duplicated genes that arose during an ancient whole genome duplication event. Many of these rapidly evolving paralogues have acquired new or more specialized functions that are less essential for growth. Th

SUBMITTER: Burhans DT 

PROVIDER: S-EPMC1550265 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature