U.S. Human immunodeficiency virus type 1 epidemic: date of origin, population history, and characterization of early strains.

ABSTRACT: Human immunodeficiency virus (HIV) type 1 subtype B sequences (whole envelope and the p17 region of gag) were obtained from peripheral blood mononuclear cell samples collected in 1981 from seven HIV-infected U.S. individuals and in 1982 from one infected Canadian resident. Phylogenetic and nucleotide distance analyses were performed by using database sequences representing North American strains collected from 1978 to 1995. The estimated phylogeny was starlike, with early strains represented on different lineages. When sequences were grouped by years of collection, nucleotide distance comparisons demonstrated an increase in diversity over time and indicated that contemporary strains are more closely related to early epidemic strains than to each other. Using a recently developed likelihood

SUBMITTER: Robbins KE 

PROVIDER: S-EPMC155028 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature