A direct comparison of protein interaction confidence assignment schemes.

ABSTRACT:

Background

Recent technological advances have enabled high-throughput measurements of protein-protein interactions in the cell, producing large protein interaction networks for various species at an ever-growing pace. However, common technologies like yeast two-hybrid may experience high rates of false positive detection. To combat false positive discoveries, a number of different methods have been recently developed that associate confidence scores with protein interactions. Here, we perform a rigorous comparative analysis and performance assessment among these different methods.

Results

We measure the extent to which each set of confidence scores correlates with similarity of the interacting proteins in terms of function, expression, pattern of sequence conservation, and h

SUBMITTER: Suthram S 

PROVIDER: S-EPMC1550431 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature