Large scale copy number variation (CNV) at 14q12 is associated with the presence of genomic abnormalities in neoplasia.

ABSTRACT:

Background

Advances made in the area of microarray comparative genomic hybridization (aCGH) have enabled the interrogation of the entire genome at a previously unattainable resolution. This has lead to the discovery of a novel class of alternative entities called large-scale copy number variations (CNVs). These CNVs are often found in regions of closely linked sequence homology called duplicons that are thought to facilitate genomic rearrangements in some classes of neoplasia. Recently, it was proposed that duplicons located near the recurrent translocation break points on chromosomes 9 and 22 in chronic myeloid leukemia (CML) may facilitate this tumor-specific translocation. Furthermore, approximately 15-20% of CML patients also carry a microdeletion on the derivative 9 chromosome

SUBMITTER: Braude I 

PROVIDER: S-EPMC1550726 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature