Statins in the treatment of chronic heart failure: a systematic review.

ABSTRACT:

Background

The efficacy of statin therapy in patients with established chronic heart failure (CHF) is a subject of much debate.

Methods and findings

We conducted three systematic literature searches to assess the evidence supporting the prescription of statins in CHF. First, we investigated the participation of CHF patients in randomized placebo-controlled clinical trials designed to evaluate the efficacy of statins in reducing major cardiovascular events and mortality. Second, we assessed the association between serum cholesterol and outcome in CHF. Finally, we evaluated the ability of statin treatment to modify surrogate endpoint parameters in CHF. Using validated search strategies, we systematically searched PubMed for our three queries. In addition, we searched the refer

SUBMITTER: van der Harst P 

PROVIDER: S-EPMC1551909 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature