Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury.

ABSTRACT:

Background

Childhood obstructive sleep apnea (OSA) is associated with neuropsychological deficits of memory, learning, and executive function. There is no evidence of neuronal brain injury in children with OSA. We hypothesized that childhood OSA is associated with neuropsychological performance dysfunction, and with neuronal metabolite alterations in the brain, indicative of neuronal injury in areas corresponding to neuropsychological function.

Methods and findings

We conducted a cross-sectional study of 31 children (19 with OSA and 12 healthy controls, aged 6-16 y) group-matched by age, ethnicity, gender, and socioeconomic status. Participants underwent polysomnography and neuropsychological assessments. Proton magnetic resonance spectroscopic imaging was performed on a sub

SUBMITTER: Halbower AC 

PROVIDER: S-EPMC1551912 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature