PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins.

ABSTRACT: Despite significant structural diversity, present evidence suggests that EWS/ETS fusion proteins promote oncogenesis by transcriptionally modulating a common set of target genes. In order to identify these genes, microarray expression analyses were performed on NIH 3T3 polyclonal populations expressing one of three EWS/ETS fusion genes. The majority of these genes can be grouped into seven functional categories, including cellular metabolism and signal transduction. The biologic significance of these target genes was pursued. The effects of modulating genes involved in metabolism were assessed by flux studies and demonstrated shifts in glucose utilization and lactate production as a result of EWS/FLI1 expression. The proto-oncogene coding for serine/threonine kinase PIM3 was found to one o

SUBMITTER: Deneen B 

PROVIDER: S-EPMC155223 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature