Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.

ABSTRACT: Various studies have demonstrated a role for E2F proteins in the control of transcription of genes involved in DNA replication, cell cycle progression, and cell fate determination. Although it is clear that the functions of the E2F proteins overlap, there is also evidence for specific roles for individual E2F proteins in the control of apoptosis and cell proliferation. Investigating protein interactions that might provide a mechanistic basis for the specificity of E2F function, we identified the E-box binding factor TFE3 as an E2F3-specific partner. We also show that this interaction is dependent on the marked box domain of E2F3. We provide evidence for a role for TFE3 in the synergistic activation of the p68 subunit gene of DNA polymerase alpha together with E2F3, again dependent on the E

SUBMITTER: Giangrande PH 

PROVIDER: S-EPMC155231 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature