Cross-referencing eukaryotic genomes: TIGR Orthologous Gene Alignments (TOGA).

ABSTRACT: Comparative genomics promises to rapidly accelerate the identification and functional classification of biologically important human genes. We developed the TIGR Orthologous Gene Alignment (TOGA; ) database to provide a cross-reference between fully and partially sequenced eukaryotic transcribed sequences. Starting with the assembled expressed sequence tag (EST) and gene sequences that comprise the 28 TIGR Gene Indices, we used high-stringency pair-wise sequence searches and a reflexive, transitive closure process to associate sequence-specific best hits, generating 32,652 tentative ortholog groups (TOGs). This has allowed us to identify putative orthologs and paralogs for known genes, as well as those that exist only as uncharacterized ESTs and to

SUBMITTER: Lee Y 

PROVIDER: S-EPMC155294 | biostudies-literature | 2002 Mar

REPOSITORIES: biostudies-literature