Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes.

ABSTRACT:

Background

Mouse strains with a contrasting response to morphine provide a unique model for studying the genetically determined diversity of sensitivity to opioid reward, tolerance and dependence. Four inbred strains selected for this study exhibit the most distinct opioid-related phenotypes. C57BL/6J and DBA/2J mice show remarkable differences in morphine-induced antinociception, self-administration and locomotor activity. 129P3/J mice display low morphine tolerance and dependence in contrast to high sensitivity to precipitated withdrawal observed in SWR/J and C57BL/6J strains. In this study, we attempted to investigate the relationships between genetic background and basal gene expression profile in the striatum, a brain region involved in the mechanism of opioid action.

Resul

SUBMITTER: Korostynski M 

PROVIDER: S-EPMC1553451 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature