Comparative genomics of the class 4 histone deacetylase family indicates a complex evolutionary history.

ABSTRACT:

Background

Histone deacetylases are enzymes that modify core histones and play key roles in transcriptional regulation, chromatin assembly, DNA repair, and recombination in eukaryotes. Three types of related histone deacetylases (classes 1, 2, and 4) are widely found in eukaryotes, and structurally related proteins have also been found in some prokaryotes. Here we focus on the evolutionary history of the class 4 histone deacetylase family.

Results

Through sequence similarity searches against sequenced genomes and expressed sequence tag data, we identified members of the class 4 histone deacetylase family in 45 eukaryotic and 37 eubacterial species representative of very distant evolutionary lineages. Multiple phylogenetic analyses indicate that the phylogeny of these protein

SUBMITTER: Ledent V 

PROVIDER: S-EPMC1555614 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature