Longitudinal monitoring of lung injury in children after acute chlorine exposure in a swimming pool.

ABSTRACT:

Rationale

Acute exposure to chlorine gas results in respiratory impairment, but few data are available on the pathobiology of the underlying lung damage.

Objectives

To assess lung function and potential lung damage pathways in the acute phase and longitudinally over a 15-mo follow-up after acute chlorine exposure.

Methods

Ten previously healthy children were accidentally exposed to chlorine gas at a swimming pool because of an erroneous servicing procedure. The fraction of nitric oxide in exhaled air (Fe(NO)), exhaled breath condensate compounds, and serum Clara cell-specific protein CC16 were repeatedly measured.

Main results

In the acute phase, all patients had respiratory distress (one child required mechanical ventilation) and reduced lung function (median

SUBMITTER: Bonetto G 

PROVIDER: S-EPMC1555620 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature