Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes.

ABSTRACT: The identification of the cystic fibrosis transmembrane conductance regulator gene (CFTR) in 1989 represents a landmark accomplishment in human genetics. Since that time, there have been numerous advances in elucidating the function of the encoded protein and the physiological basis of cystic fibrosis. However, numerous areas of cystic fibrosis biology require additional investigation, some of which would be facilitated by information about the long-range sequence context of the CFTR gene. For example, the latter might provide clues about the sequence elements responsible for the temporal and spatial regulation of CFTR expression. We thus sought to establish the sequence of the chromosomal segments encompassing the human CFTR and mouse Cftr genes, with the hope of identifying conserved reg

SUBMITTER: Ellsworth RE 

PROVIDER: S-EPMC15558 | biostudies-literature | 2000 Feb

REPOSITORIES: biostudies-literature