TOX defines a conserved subfamily of HMG-box proteins.

ABSTRACT:

Background

HMG-box proteins are a large and diverse superfamily of architectural factors that share one or more copies of a sequence- and structurally-related DNA binding domain. These proteins can modify chromatin structure by bending and unwinding DNA. HMG-box proteins can be divided into two subfamilies based on whether they recognize DNA in a sequence-dependent or sequence-independent manner. We recently identified an HMG-box protein involved in T cell development, designated TOX, which is highly conserved in humans and mice.

Results

We show here that based on sequence alignment, TOX best fits into the sequence-independent HMG-box family. Three other human and murine predicted proteins are identified that share a common HMG-box domain with TOX, as well as other features.

SUBMITTER: O'Flaherty E 

PROVIDER: S-EPMC155677 | biostudies-literature | 2003 Apr

REPOSITORIES: biostudies-literature