Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel.

ABSTRACT:

Background

Tumor promoters enhance tumor yield in experimental animals without directly affecting the DNA of the cell. Promoters may play a role in the development of cancer, as humans are exposed to them in the environment. In work based on computer-assisted microscopy and sophisticated classification methods, we showed that cells could be classified by reference to a database of known normal and cancerous cell phenotypes. Promoters caused loss of properties specific to normal cells and gain of properties of cancer cells. Other compounds, including colchicine, had a similar effect. Colchicine given together with paclitaxel, however, caused cells to adopt properties of normal cells. This provided a rationale for tests of microtubule inhibitor combinations in cancer patients. The co

SUBMITTER: Bombuwala K 

PROVIDER: S-EPMC1557522 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature