Evidence of influence of genomic DNA sequence on human X chromosome inactivation.

ABSTRACT: A significant number of human X-linked genes escape X chromosome inactivation and are thus expressed from both the active and inactive X chromosomes. The basis for escape from inactivation and the potential role of the X chromosome primary DNA sequence in determining a gene's X inactivation status is unclear. Using a combination of the X chromosome sequence and a comprehensive X inactivation profile of more than 600 genes, two independent yet complementary approaches were used to systematically investigate the relationship between X inactivation and DNA sequence features. First, statistical analyses revealed that a number of repeat features, including long interspersed nuclear element (LINE) and mammalian-wide interspersed repeat repetitive elements, are significantly enriched in regions s

SUBMITTER: Wang Z 

PROVIDER: S-EPMC1557588 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature