Histology-based expression profiling yields novel prognostic markers in human glioblastoma.

ABSTRACT: Although the prognosis for patients with glioblastoma is poor, survival is variable, with some patients surviving longer than others. For this reason, there has been longstanding interest in the identification of prognostic markers for glioblastoma. We hypothesized that specific histologic features known to correlate with malignancy most likely express molecules that are directly related to the aggressive behavior of these tumors. We further hypothesized that such molecules could be used as biomarkers to predict behavior in a manner that might add prognostic power to sole histologic observation of the feature. We reasoned that perinecrotic tumor cell palisading, which denotes the most aggressive forms of malignant gliomas, would be a striking histologic feature on which to test this hypoth

SUBMITTER: Dong S 

PROVIDER: S-EPMC1557632 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature