Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains.

ABSTRACT:

Background

The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a standardized and quantitative technique, TaqMan RT-PCR, should give information about the pattern and relative importance of TRP channels for murine tissues and cell types. To verify data sets with an independent method, we studied the occurrence of some of the transcripts by in situ hybridization.

Results

We have characterized the mRNA expression of 22 TRP channels in the mouse with a focus on nerve and muscle tissues. This is the first study to describe the expression profiles of all channel isoforms of the four related Group 1 subfamilies (TRPC, TRPV, TRPM and TRPA) with a standardized and quantitative technique. Comparison

SUBMITTER: Kunert-Keil C 

PROVIDER: S-EPMC1557673 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature