Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone.

ABSTRACT:

Introduction

Studies in xenograft models and experimental models of metastasis have implicated several beta3 integrin-expressing cell populations, including endothelium, platelets and osteoclasts, in breast tumor progression. Since orthotopic human xenograft models of breast cancer are poorly metastatic to bone and experimental models bypass the formation of a primary tumor, however, the precise contribution of tumor-specific alphavbeta3 to the spontaneous metastasis of breast tumors from the mammary gland to bone remains unclear.

Methods

We used a syngeneic orthotopic model of spontaneous breast cancer metastasis to test whether exogenous expression of alphavbeta3 in a mammary carcinoma line (66cl4) that metastasizes to the lung, but not to bone, was sufficient to promote i

SUBMITTER: Sloan EK 

PROVIDER: S-EPMC1557720 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature