Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model.

ABSTRACT: Individual genetic admixture estimates, determined both across the genome and at specific genomic regions, have been proposed for use in identifying specific genomic regions harboring loci influencing phenotypes in regional admixture mapping (RAM). Estimates of individual ancestry can be used in structured association tests (SAT) to reduce confounding induced by various forms of population substructure. Although presented as two distinct approaches, we provide a conceptual framework in which both RAM and SAT are special cases of a more general linear model. We clarify which variables are sufficient to condition upon in order to prevent spurious associations and also provide a simple closed form "semiparametric" method of evaluating the reliability of individual admixture estimates. An esti

SUBMITTER: Redden DT 

PROVIDER: S-EPMC1557785 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature