Integrated regulation of the type III secretion system and other virulence determinants in Ralstonia solanacearum.

ABSTRACT: In many plant and animal bacterial pathogens, the Type III secretion system (TTSS) that directly translocates effector proteins into the eukaryotic host cells is essential for the development of disease. In all species studied, the transcription of the TTSS and most of its effector substrates is tightly regulated by a succession of consecutively activated regulators. However, the whole genetic programme driven by these regulatory cascades is still unknown, especially in bacterial plant pathogens. Here, we have characterised the programme triggered by HrpG, a host-responsive regulator of the TTSS activation cascade in the plant pathogen Ralstonia solanacearum. We show through genome-wide expression analysis that, in addition to the TTSS, HrpG controls the expression of a previously undescri

SUBMITTER: Valls M 

PROVIDER: S-EPMC1557829 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature