Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins.

ABSTRACT:

Background

The WW domain is found in a large number of eukaryotic proteins implicated in a variety of cellular processes. WW domains bind proline-rich protein and peptide ligands, but the protein interaction partners of many WW domain-containing proteins in Saccharomyces cerevisiae are largely unknown.

Results

We used protein microarray technology to generate a protein interaction map for 12 of the 13 WW domains present in proteins of the yeast S. cerevisiae. We observed 587 interactions between these 12 domains and 207 proteins, most of which have not previously been described. We analyzed the representation of functional annotations within the network, identifying enrichments for proteins with peroxisomal localization, as well as for proteins involved in protein turnover a

SUBMITTER: Hesselberth JR 

PROVIDER: S-EPMC1557994 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature