Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.

ABSTRACT: Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.

SUBMITTER: Choudhry AE 

PROVIDER: S-EPMC155856 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature