Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.

ABSTRACT: Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.

SUBMITTER: Tosic M 

PROVIDER: S-EPMC1559555 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature