A joint model of regulatory and metabolic networks.

ABSTRACT:

Background

Gene regulation and metabolic reactions are two primary activities of life. Although many works have been dedicated to study each system, the coupling between them is less well understood. To bridge this gap, we propose a joint model of gene regulation and metabolic reactions.

Results

We integrate regulatory and metabolic networks by adding links specifying the feedback control from the substrates of metabolic reactions to enzyme gene expressions. We adopt two alternative approaches to build those links: inferring the links between metabolites and transcription factors to fit the data or explicitly encoding the general hypotheses of feedback control as links between metabolites and enzyme expressions. A perturbation data is explained by paths in the joint network

SUBMITTER: Yeang CH 

PROVIDER: S-EPMC1559649 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature