MANET: tracing evolution of protein architecture in metabolic networks.

ABSTRACT:

Background

Cellular metabolism can be characterized by networks of enzymatic reactions and transport processes capable of supporting cellular life. Our aim is to find evolutionary patterns and processes embedded in the architecture and function of modern metabolism, using information derived from structural genomics.

Description

The Molecular Ancestry Network (MANET) project traces evolution of protein architecture in biomolecular networks. We describe metabolic MANET, a database that links information in the Structural Classification of Proteins (SCOP), the Kyoto Encyclopedia of Genes and Genomes (KEGG), and phylogenetic reconstructions depicting the evolution of protein fold architecture. Metabolic MANET literally 'paints' the ancestries of enzymes derived from rooted phyl

SUBMITTER: Kim HS 

PROVIDER: S-EPMC1559654 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature