Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity.

ABSTRACT:

Background

At least three species of Borrelia burgdorferi sensu lato (Bbsl) cause tick-borne Lyme disease. Previous work including the genome analysis of B. burgdorferi B31 and B. garinii PBi suggested a highly variable plasmid part. The frequent occurrence of duplicated sequence stretches, the observed plasmid redundancy, as well as the mainly unknown function and variability of plasmid encoded genes rendered the relationships between plasmids within and between species largely unresolvable.

Results

To gain further insight into Borreliae genome properties we completed the plasmid sequences of B. garinii PBi, added the genome of a further species, B. afzelii PKo, to our analysis, and compared for both species the genomes of pathogenic and apathogenic strains. The core of all

SUBMITTER: Glockner G 

PROVIDER: S-EPMC1559707 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature