Alteration of gene expression profiles during mycoplasma-induced malignant cell transformation.

ABSTRACT:

Background

Mycoplasmas are the smallest microorganisms capable of self-replication. Our previous studies show that some mycoplasmas are able to induce malignant transformation of host mammalian cells. This malignant transformation is a multistage process with the early infection, reversible and irreversible stages, and similar to human tumor development in nature. The purpose of this study is to explore mechanisms for this malignant transformation.

Methods

To better understand mechanisms for this unique process, we examined gene expression profiles of C3H cells at different stages of the mycoplasma-induced transformation using cDNA microarray technology. A total of 1185 genes involved in oncogenesis, apoptosis, cell growth, cell-cycle regulation, DNA repair, etc. were examin

SUBMITTER: Zhang S 

PROVIDER: S-EPMC1559712 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature