Role of common human TRIM5alpha variants in HIV-1 disease progression.

ABSTRACT:

Background

The retroviral restriction factor tripartite motif protein (TRIM)5alpha, is characterized by marked amino acid diversity among primates, including specific clusters of residues under positive selection. The identification of multiple non-synonymous changes in humans suggests that TRIM5alpha variants might be relevant to retroviral pathogenesis. Previous studies have shown that such variants are unlikely to modify susceptibility to HIV-1 infection, or the course of early infection. However, the longterm effect of carrying Trim5alpha variants on disease progression in individuals infected with HIV-1 has not previously been investigated.

Methods

In a cohort of 979 untreated individuals infected with HIV-1 with median follow up 3.2 years and 9,828 CD4 T cell measureme

SUBMITTER: Goldschmidt V 

PROVIDER: S-EPMC1560158 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature