Astrocytes derived from glial-restricted precursors promote spinal cord repair.

ABSTRACT:

Background

Transplantation of embryonic stem or neural progenitor cells is an attractive strategy for repair of the injured central nervous system. Transplantation of these cells alone to acute spinal cord injuries has not, however, resulted in robust axon regeneration beyond the sites of injury. This may be due to progenitors differentiating to cell types that support axon growth poorly and/or their inability to modify the inhibitory environment of adult central nervous system (CNS) injuries. We reasoned therefore that pre-differentiation of embryonic neural precursors to astrocytes, which are thought to support axon growth in the injured immature CNS, would be more beneficial for CNS repair.

Results

Transplantation of astrocytes derived from embryonic glial-restricted prec

SUBMITTER: Davies JE 

PROVIDER: S-EPMC1561531 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature