Identification and classification of human cytomegalovirus capsids in textured electron micrographs using deformed template matching.

ABSTRACT:

Background

Characterization of the structural morphology of virus particles in electron micrographs is a complex task, but desirable in connection with investigation of the maturation process and detection of changes in viral particle morphology in response to the effect of a mutation or antiviral drugs being applied. Therefore, we have here developed a procedure for describing and classifying virus particle forms in electron micrographs, based on determination of the invariant characteristics of the projection of a given virus structure. The template for the virus particle is created on the basis of information obtained from a small training set of electron micrographs and is then employed to classify and quantify similar structures of interest in an unlimited number of electron m

SUBMITTER: Ryner M 

PROVIDER: S-EPMC1563456 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature