A comparison of Pfam and MEROPS: two databases, one comprehensive, and one specialised.

ABSTRACT:

Background

We wished to compare two databases based on sequence similarity: one that aims to be comprehensive in its coverage of known sequences, and one that specialises in a relatively small subset of known sequences. One of the motivations behind this study was quality control. Pfam is a comprehensive collection of alignments and hidden Markov models representing families of proteins and domains. MEROPS is a catalogue and classification of enzymes with proteolytic activity (peptidases or proteases). These secondary databases are used by researchers worldwide, yet their contents are not peer reviewed. Therefore, we hoped that a systematic comparison of the contents of Pfam and MEROPS would highlight missing members and false-positives leading to improvements in quality of both da

SUBMITTER: Studholme DJ 

PROVIDER: S-EPMC156619 | biostudies-literature | 2003 May

REPOSITORIES: biostudies-literature