Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals.

ABSTRACT: The Src family of tyrosine kinases play pivotal roles in regulating cellular functions characteristic of multicellular animals, including cell-cell interactions, cell-substrate adhesion, and cell migration. To investigate the functional alteration of Src kinases during evolution from a unicellular ancestor to multicellular animals, we characterized Src orthologs from the unicellular choanoflagellate Monosiga ovata and the primitive multicellular sponge Ephydatia fluviatilis. Here, we show that the src gene family and its C-terminal Src kinase (Csk)-mediated regulatory system already were established in the unicellular M. ovata and that unicellular Src has unique features relative to multicellular Src: It can be phosphorylated by Csk at the negative regulatory site but still exhibits substa

SUBMITTER: Segawa Y 

PROVIDER: S-EPMC1567691 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature