Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells.

ABSTRACT: Smooth muscle is a major component of human tissues and is essential for the normal function of a multitude of organs including the intestine, urinary tract and the vascular system. The use of stem cells for cell-based tissue engineering and regeneration strategies represents a promising alternative for smooth muscle repair. For such strategies to succeed, a reliable source of smooth muscle precursor cells must be identified. Adipose tissue provides an abundant source of multipotent cells. In this study, the capacity of processed lipoaspirate (PLA) and adipose-derived stem cells to differentiate into phenotypic and functional smooth muscle cells was evaluated. To induce differentiation, PLA cells were cultured in smooth muscle differentiation medium. Smooth muscle differentiation of PLA ce

SUBMITTER: Rodriguez LV 

PROVIDER: S-EPMC1567713 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature