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Neocortical neurogenesis in humans is restricted to development.

ABSTRACT: Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of (14)C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally.

SUBMITTER: Bhardwaj RD

PROVIDER: S-EPMC1567918 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature

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Neocortical neurogenesis in humans is restricted to development.

Bhardwaj Ratan D RD Curtis Maurice A MA Spalding Kirsty L KL Buchholz Bruce A BA Fink David D Björk-Eriksson Thomas T Nordborg Claes C Gage Fred H FH Druid Henrik H Eriksson Peter S PS Frisén Jonas J

Proceedings of the National Academy of Sciences of the United States of America 20060810 33

Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of (14)C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our ...[more]

PMID: 16901981

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