Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids.

ABSTRACT: Oxidized phospholipids are thought to promote atherogenesis by stimulating endothelial cells (ECs) to produce inflammatory cytokines, such as IL-8. In studies with mouse models, we previously demonstrated that genetic variation in inflammatory responses of endothelial cells to oxidized lipids contributes importantly to atherosclerosis susceptibility. We now show that similar variations occur in cultured aortic ECs derived from multiple heart transplant donors. These variations were stably maintained between passages and, thus, reflect either genetic or epigenetic regulatory differences. Expression array analysis of aortic EC cultures derived from 12 individuals revealed that >1,000 genes were regulated by oxidized phospholipids. We have used the observed variations in the sampled populatio

SUBMITTER: Gargalovic PS 

PROVIDER: S-EPMC1568918 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature