Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial.

ABSTRACT:

Objectives

Previous studies have shown that in children with severe malaria, resuscitation with albumin infusion results in a lower mortality than resuscitation with saline infusion. Whether the apparent benefit of albumin is due solely to its colloidal properties, and thus might also be achieved with other synthetic colloids, or due to the many other unique physiological properties of albumin is unknown. As albumin is costly and not readily available in Africa, examination of more affordable colloids is warranted. In order to inform the design of definitive phase III trials we compared volume expansion with Gelofusine (succinylated modified fluid gelatin 4% intravenous infusion) with albumin.

Design

This study was a phase II safety and efficacy study.

Setting

The stu

SUBMITTER: Akech S 

PROVIDER: S-EPMC1569382 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature