Lipid rafts and regulation of the cytoskeleton during T cell activation.

ABSTRACT: The ability of polarized cells to initiate and sustain directional responses to extracellular signals is critically dependent on direct communication between spatially organized signalling modules in the membrane and the underlying cytoskeleton. Pioneering work in T cells has shown that the assembly of signalling modules critically depends on the functional compartmentalization of membrane lipids into ordered microdomains or lipid rafts. The significance of rafts in T cell activation lies not only in their ability to recruit the signalling partners that eventually assemble into a mature immunological synapse but also in their ability to regulate actin dynamics and recruit cytoskeletal associated proteins, thereby achieving the structural polarization underlying stability of the synapse-a c

SUBMITTER: Meiri KF 

PROVIDER: S-EPMC1569545 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature