Phylogenetic evidence for inter-typic recombination in the emergence of human enterovirus 71 subgenotypes.

ABSTRACT:

Background

Human enterovirus 71 (EV-71) is a common causative agent of hand, foot and mouth disease (HFMD). In recent years, the virus has caused several outbreaks with high numbers of deaths and severe neurological complications. Several new EV-71 subgenotypes were identified from these outbreaks. The mechanisms that contributed to the emergence of these subgenotypes are unknown.

Results

Six EV-71 isolates from an outbreak in Malaysia, in 1997, were sequenced completely. These isolates were identified as EV-71 subgenotypes, B3, B4 and C2. A phylogenetic tree that correlated well with the present enterovirus classification scheme was established using these full genome sequences and all other available full genome sequences of EV-71 and human enterovirus A (HEV-A). Using the

SUBMITTER: Yoke-Fun C 

PROVIDER: S-EPMC1569848 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature