Evaluation of CXCL9 and CXCL10 as circulating biomarkers of human cardiac allograft rejection.

ABSTRACT:

Background

Cardiac allograft rejection remains a significant clinical problem in the early phase after heart transplantation and requires frequent surveillance with endomyocardial biopsy. However, this is an invasive procedure, which is unpleasant for the patient and carries a certain risk. Therefore, a sensitive non-invasive biomarker of acute rejection would be desirable.

Methods

Endomyocardial tissue samples and serum were obtained in connection with clinical biopsies from twenty consecutive heart transplant patients followed for six months. A rejection episode was observed in 14 patients (11 men and 3 women) and biopsies obtained before, during and after the episode were identified. Endomyocardial RNA, from three patients, matching these three points in time were analyse

SUBMITTER: Karason K 

PROVIDER: S-EPMC1569871 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature