UVPAR: fast detection of functional shifts in duplicate genes.

ABSTRACT:

Background

The imprint of natural selection on gene sequences is often difficult to detect. A plethora of methods have been devised to detect genetic changes due to selective processes. However, many of those methods depend heavily on underlying assumptions regarding the mode of change of DNA sequences and often require sophisticated mathematical treatments that made them computationally slow. The development of fast and effective methods to detect modifications in the selective constraints of genes is therefore of great interest.

Results

We describe UVPAR, a program designed to quickly test for changes in the functional constraints of duplicate genes. Starting with alignments of the proteins encoded by couples of duplicate genes in two different species, UVPAR detects the r

SUBMITTER: Arnau V 

PROVIDER: S-EPMC1570150 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature