Tools for integrated sequence-structure analysis with UCSF Chimera.

ABSTRACT:

Background

Comparing related structures and viewing the structures in the context of sequence alignments are important tasks in protein structure-function research. While many programs exist for individual aspects of such work, there is a need for interactive visualization tools that: (a) provide a deep integration of sequence and structure, far beyond mapping where a sequence region falls in the structure and vice versa; (b) facilitate changing data of one type based on the other (for example, using only sequence-conserved residues to match structures, or adjusting a sequence alignment based on spatial fit); (c) can be used with a researcher's own data, including arbitrary sequence alignments and annotations, closely or distantly related sets of proteins, etc.; and (d) interoperat

SUBMITTER: Meng EC 

PROVIDER: S-EPMC1570152 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature