Altered gene expression in asymptomatic SHIV-infected rhesus macaques (Macacca mulatta).

ABSTRACT: Simian-Human immunodeficiency virus is a chimeric virus which, in rhesus macaques (Macacca mulatta) closely imitates immunodeficiency virus infection in human (HIV). A relatively new way to study pathogenesis of viral infection is to study alterations in host gene expression induced by the virus. SHIV infection with certain strains does not result in clinical signs. We hypothesized that alterations in gene expression relating to the immune system would be present in SHIV-infected animals despite the lack of clinical signs. Splenic tissue from four adult male Indian-origin Rhesus monkeys serologically positive for non-pathogenic SHIV 89.6 was processed by cDNA microarray analysis. Results were compared with the corresponding outcome using splenic tissues from four unexposed adult male Rhesu

SUBMITTER: Carroll EE 

PROVIDER: S-EPMC1570341 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature