Two-stage two-locus models in genome-wide association.

ABSTRACT: Studies in model organisms suggest that epistasis may play an important role in the etiology of complex diseases and traits in humans. With the era of large-scale genome-wide association studies fast approaching, it is important to quantify whether it will be possible to detect interacting loci using realistic sample sizes in humans and to what extent undetected epistasis will adversely affect power to detect association when single-locus approaches are employed. We therefore investigated the power to detect association for an extensive range of two-locus quantitative trait models that incorporated varying degrees of epistasis. We compared the power to detect association using a single-locus model that ignored interaction effects, a full two-locus model that allowed for interactions, and,

SUBMITTER: Evans DM 

PROVIDER: S-EPMC1570380 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature