Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice.

ABSTRACT: To explore the potential involvement of aberrant Notch1 signaling in breast cancer pathogenesis, we have used a transgenic mouse model. In these animals, mouse mammary tumor virus LTR-driven expression of the constitutively active intracellular domain of the Notch1 receptor (N1(IC)) causes development of lactation-dependent mammary tumors that regress upon gland involution but progress to nonregressing, invasive adenocarcinomas in subsequent pregnancies. Up-regulation of Myc in these tumors prompted a genetic investigation of a potential Notch1/Myc functional relationship in breast carcinogenesis. Conditional ablation of Myc in the mammary epithelium prevented the induction of regressing N1(IC) neoplasms and also reduced the incidence of nonregressing carcinomas, which developed with signi

SUBMITTER: Klinakis A 

PROVIDER: S-EPMC1570422 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature