Caveolin-1 interacts with the Gag precursor of murine leukaemia virus and modulates virus production.

ABSTRACT:

Background

Retroviral Gag determines virus assembly at the plasma membrane and the formation of virus-like particles in intracellular multivesicular bodies. Thereby, retroviruses exploit by interaction with cellular partners the cellular machineries for vesicular transport in various ways.

Results

The retroviral Gag precursor protein drives assembly of murine leukaemia viruses (MLV) at the plasma membrane (PM) and the formation of virus like particles in multivesicular bodies (MVBs). In our study we show that caveolin-1 (Cav-1), a multifunctional membrane-associated protein, co-localizes with Gag in a punctate pattern at the PM of infected NIH 3T3 cells. We provide evidence that Cav-1 interacts with the matrix protein (MA) of the Gag precursor. This interaction is mediated b

SUBMITTER: Yu Z 

PROVIDER: S-EPMC1570462 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature