Effects of the oestrous cycle and gender on acute vasodilatory responses of isolated pressurized rat mesenteric arteries to 17 beta-oestradiol.

ABSTRACT: The influence of the oestrous cycle and gender on responses of isolated pressurized mesenteric arteries to acute 17 beta-oestradiol was investigated. All vessels, pre-contracted with 60 mM KCl or 10 microM U46619 (9,11 dideoxy-11alpha, 9alpha-epoxy methano-prostaglandin), exhibited concentration-dependent vasodilatory responses to 17 beta-oestradiol (3 - 30 microM). The largest responses were seen in vessels from female rats in pro-oestrous (38.9+/-5.4% U46619 max and 63.1+/-4.0% KCl max for 30 microM oestradiol), the smallest from animals in di-oestrous (20.1+/-3.7% U46619 and 50.1+/-4.5% KCL - both P:<0.05 cf pro-oestrous (all n=8)). Responses of vessels from male rats were similar to those from pro-oestrous rats (41.5+/-9.1% U46619 (n=10) and 54.9+/-2.9% KCl (n =8)). All responsees were

SUBMITTER: Shaw L 

PROVIDER: S-EPMC1572647 | biostudies-literature | 2001 Mar

REPOSITORIES: biostudies-literature